p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock
Identifieur interne : 000739 ( Main/Exploration ); précédent : 000738; suivant : 000740p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock
Auteurs : Antonella Cotoia [Italie] ; Rosella Scrima [Italie] ; Julia V. Gefter [États-Unis] ; Claudia Piccoli [Italie] ; Gilda Cinnella [Italie] ; Michele Dambrosio [Italie] ; Mitchell P. Fink [États-Unis] ; Nazzareno Capitanio [Italie]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Acides benzènepyruviques (pharmacologie), Acides benzènepyruviques (usage thérapeutique), Analyse de survie, Animaux, Choc hémorragique (), Choc hémorragique (métabolisme), Choc hémorragique (physiopathologie), Choc hémorragique (traitement médicamenteux), Espèces réactives de l'oxygène (métabolisme), Fractions subcellulaires (), Fractions subcellulaires (métabolisme), Humains, Hémodynamique (), Lignée cellulaire, Mitochondries (), Mitochondries (métabolisme), Oxydoréduction, Phénylalanine (métabolisme), Prolifération cellulaire (), Rats, Respiration cellulaire (), Stress physiologique (), Superoxydes (métabolisme), Survie cellulaire (), Tyrosine (métabolisme), Voies et réseaux métaboliques ().
- MESH :
- métabolisme : Choc hémorragique, Espèces réactives de l'oxygène, Fractions subcellulaires, Mitochondries, Phénylalanine, Superoxydes, Tyrosine.
- pharmacologie : Acides benzènepyruviques.
- physiopathologie : Choc hémorragique.
- traitement médicamenteux : Choc hémorragique.
- usage thérapeutique : Acides benzènepyruviques.
- Analyse de survie, Animaux, Choc hémorragique, Fractions subcellulaires, Humains, Hémodynamique, Lignée cellulaire, Mitochondries, Oxydoréduction, Prolifération cellulaire, Rats, Respiration cellulaire, Stress physiologique, Survie cellulaire, Voies et réseaux métaboliques.
English descriptors
- KwdEn :
- Animals, Cell Line, Cell Proliferation (drug effects), Cell Respiration (drug effects), Cell Survival (drug effects), Hemodynamics (drug effects), Humans, Metabolic Networks and Pathways (drug effects), Mitochondria (drug effects), Mitochondria (metabolism), Oxidation-Reduction, Phenylalanine (metabolism), Phenylpyruvic Acids (pharmacology), Phenylpyruvic Acids (therapeutic use), Rats, Reactive Oxygen Species (metabolism), Shock, Hemorrhagic (chemically induced), Shock, Hemorrhagic (drug therapy), Shock, Hemorrhagic (metabolism), Shock, Hemorrhagic (physiopathology), Stress, Physiological (drug effects), Subcellular Fractions (drug effects), Subcellular Fractions (metabolism), Superoxides (metabolism), Survival Analysis, Tyrosine (metabolism).
- MESH :
- chemical , metabolism : Phenylalanine, Reactive Oxygen Species, Superoxides, Tyrosine.
- chemically induced : Shock, Hemorrhagic.
- drug effects : Cell Proliferation, Cell Respiration, Cell Survival, Hemodynamics, Metabolic Networks and Pathways, Mitochondria, Stress, Physiological, Subcellular Fractions.
- drug therapy : Shock, Hemorrhagic.
- metabolism : Mitochondria, Shock, Hemorrhagic, Subcellular Fractions.
- chemical , pharmacology : Phenylpyruvic Acids.
- physiopathology : Shock, Hemorrhagic.
- chemical , therapeutic use : Phenylpyruvic Acids.
- Animals, Cell Line, Humans, Oxidation-Reduction, Rats, Survival Analysis.
Abstract
The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2–4% of the estimated blood volume of pHPP survived significantly longer (p<0.001) than rats treated with vehicle. In vitro analysis on cultured EA.hy 926 cells demonstrated that pHPP improved cell growth rate and promoted cell survival under stressing conditions. Moreover, pHPP stimulated mitochondria-related respiration under ATP-synthesizing conditions and exhibited antioxidant activity toward mitochondria-generated reactive oxygen species. The compound effects reported in the in vitro and in vivo analyses were obtained in the same millimolar concentration range. These data disclose pHPP as an efficient energetic substrates-supplier to the mitochondrial respiratory chain as well as an antioxidant supporting the view that the compound warrants further evaluation as a therapeutic agent.
Url:
DOI: 10.1371/journal.pone.0090917
PubMed: 24599095
PubMed Central: 3944966
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001C91
- to stream Pmc, to step Curation: 001C66
- to stream Pmc, to step Checkpoint: 000010
- to stream PubMed, to step Corpus: 003609
- to stream PubMed, to step Curation: 003586
- to stream PubMed, to step Checkpoint: 003586
- to stream Ncbi, to step Merge: 001431
- to stream Ncbi, to step Curation: 001431
- to stream Ncbi, to step Checkpoint: 001431
- to stream Main, to step Merge: 000740
- to stream Main, to step Curation: 000739
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock</title><author><name sortKey="Cotoia, Antonella" sort="Cotoia, Antonella" uniqKey="Cotoia A" first="Antonella" last="Cotoia">Antonella Cotoia</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Scrima, Rosella" sort="Scrima, Rosella" uniqKey="Scrima R" first="Rosella" last="Scrima">Rosella Scrima</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Experimental Medicine, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Gefter, Julia V" sort="Gefter, Julia V" uniqKey="Gefter J" first="Julia V." last="Gefter">Julia V. Gefter</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Piccoli, Claudia" sort="Piccoli, Claudia" uniqKey="Piccoli C" first="Claudia" last="Piccoli">Claudia Piccoli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Experimental Medicine, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Cinnella, Gilda" sort="Cinnella, Gilda" uniqKey="Cinnella G" first="Gilda" last="Cinnella">Gilda Cinnella</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Dambrosio, Michele" sort="Dambrosio, Michele" uniqKey="Dambrosio M" first="Michele" last="Dambrosio">Michele Dambrosio</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Fink, Mitchell P" sort="Fink, Mitchell P" uniqKey="Fink M" first="Mitchell P." last="Fink">Mitchell P. Fink</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Surgery and Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery and Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Capitanio, Nazzareno" sort="Capitanio, Nazzareno" uniqKey="Capitanio N" first="Nazzareno" last="Capitanio">Nazzareno Capitanio</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Experimental Medicine, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24599095</idno><idno type="pmc">3944966</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944966</idno><idno type="RBID">PMC:3944966</idno><idno type="doi">10.1371/journal.pone.0090917</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001C91</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C91</idno><idno type="wicri:Area/Pmc/Curation">001C66</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C66</idno><idno type="wicri:Area/Pmc/Checkpoint">000010</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000010</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003609</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003609</idno><idno type="wicri:Area/PubMed/Curation">003586</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003586</idno><idno type="wicri:Area/PubMed/Checkpoint">003586</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003586</idno><idno type="wicri:Area/Ncbi/Merge">001431</idno><idno type="wicri:Area/Ncbi/Curation">001431</idno><idno type="wicri:Area/Ncbi/Checkpoint">001431</idno><idno type="wicri:Area/Main/Merge">000740</idno><idno type="wicri:Area/Main/Curation">000739</idno><idno type="wicri:Area/Main/Exploration">000739</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock</title><author><name sortKey="Cotoia, Antonella" sort="Cotoia, Antonella" uniqKey="Cotoia A" first="Antonella" last="Cotoia">Antonella Cotoia</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Scrima, Rosella" sort="Scrima, Rosella" uniqKey="Scrima R" first="Rosella" last="Scrima">Rosella Scrima</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Experimental Medicine, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Gefter, Julia V" sort="Gefter, Julia V" uniqKey="Gefter J" first="Julia V." last="Gefter">Julia V. Gefter</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Piccoli, Claudia" sort="Piccoli, Claudia" uniqKey="Piccoli C" first="Claudia" last="Piccoli">Claudia Piccoli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Experimental Medicine, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Cinnella, Gilda" sort="Cinnella, Gilda" uniqKey="Cinnella G" first="Gilda" last="Cinnella">Gilda Cinnella</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Dambrosio, Michele" sort="Dambrosio, Michele" uniqKey="Dambrosio M" first="Michele" last="Dambrosio">Michele Dambrosio</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author><author><name sortKey="Fink, Mitchell P" sort="Fink, Mitchell P" uniqKey="Fink M" first="Mitchell P." last="Fink">Mitchell P. Fink</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Surgery and Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery and Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Capitanio, Nazzareno" sort="Capitanio, Nazzareno" uniqKey="Capitanio N" first="Nazzareno" last="Capitanio">Nazzareno Capitanio</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Experimental Medicine, University of Foggia, Foggia</wicri:regionArea><wicri:noRegion>Foggia</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cell Proliferation (drug effects)</term><term>Cell Respiration (drug effects)</term><term>Cell Survival (drug effects)</term><term>Hemodynamics (drug effects)</term><term>Humans</term><term>Metabolic Networks and Pathways (drug effects)</term><term>Mitochondria (drug effects)</term><term>Mitochondria (metabolism)</term><term>Oxidation-Reduction</term><term>Phenylalanine (metabolism)</term><term>Phenylpyruvic Acids (pharmacology)</term><term>Phenylpyruvic Acids (therapeutic use)</term><term>Rats</term><term>Reactive Oxygen Species (metabolism)</term><term>Shock, Hemorrhagic (chemically induced)</term><term>Shock, Hemorrhagic (drug therapy)</term><term>Shock, Hemorrhagic (metabolism)</term><term>Shock, Hemorrhagic (physiopathology)</term><term>Stress, Physiological (drug effects)</term><term>Subcellular Fractions (drug effects)</term><term>Subcellular Fractions (metabolism)</term><term>Superoxides (metabolism)</term><term>Survival Analysis</term><term>Tyrosine (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides benzènepyruviques (pharmacologie)</term><term>Acides benzènepyruviques (usage thérapeutique)</term><term>Analyse de survie</term><term>Animaux</term><term>Choc hémorragique ()</term><term>Choc hémorragique (métabolisme)</term><term>Choc hémorragique (physiopathologie)</term><term>Choc hémorragique (traitement médicamenteux)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Fractions subcellulaires ()</term><term>Fractions subcellulaires (métabolisme)</term><term>Humains</term><term>Hémodynamique ()</term><term>Lignée cellulaire</term><term>Mitochondries ()</term><term>Mitochondries (métabolisme)</term><term>Oxydoréduction</term><term>Phénylalanine (métabolisme)</term><term>Prolifération cellulaire ()</term><term>Rats</term><term>Respiration cellulaire ()</term><term>Stress physiologique ()</term><term>Superoxydes (métabolisme)</term><term>Survie cellulaire ()</term><term>Tyrosine (métabolisme)</term><term>Voies et réseaux métaboliques ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phenylalanine</term><term>Reactive Oxygen Species</term><term>Superoxides</term><term>Tyrosine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Shock, Hemorrhagic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Cell Respiration</term><term>Cell Survival</term><term>Hemodynamics</term><term>Metabolic Networks and Pathways</term><term>Mitochondria</term><term>Stress, Physiological</term><term>Subcellular Fractions</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Shock, Hemorrhagic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria</term><term>Shock, Hemorrhagic</term><term>Subcellular Fractions</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Choc hémorragique</term><term>Espèces réactives de l'oxygène</term><term>Fractions subcellulaires</term><term>Mitochondries</term><term>Phénylalanine</term><term>Superoxydes</term><term>Tyrosine</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acides benzènepyruviques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phenylpyruvic Acids</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Choc hémorragique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Shock, Hemorrhagic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Phenylpyruvic Acids</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Choc hémorragique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acides benzènepyruviques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Oxidation-Reduction</term><term>Rats</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term><term>Animaux</term><term>Choc hémorragique</term><term>Fractions subcellulaires</term><term>Humains</term><term>Hémodynamique</term><term>Lignée cellulaire</term><term>Mitochondries</term><term>Oxydoréduction</term><term>Prolifération cellulaire</term><term>Rats</term><term>Respiration cellulaire</term><term>Stress physiologique</term><term>Survie cellulaire</term><term>Voies et réseaux métaboliques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2–4% of the estimated blood volume of pHPP survived significantly longer (p<0.001) than rats treated with vehicle. In vitro analysis on cultured EA.hy 926 cells demonstrated that pHPP improved cell growth rate and promoted cell survival under stressing conditions. Moreover, pHPP stimulated mitochondria-related respiration under ATP-synthesizing conditions and exhibited antioxidant activity toward mitochondria-generated reactive oxygen species. The compound effects reported in the in vitro and in vivo analyses were obtained in the same millimolar concentration range. These data disclose pHPP as an efficient energetic substrates-supplier to the mitochondrial respiratory chain as well as an antioxidant supporting the view that the compound warrants further evaluation as a therapeutic agent.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peitzman, Ab" uniqKey="Peitzman A">AB Peitzman</name></author><author><name sortKey="Billiar, Tr" uniqKey="Billiar T">TR Billiar</name></author><author><name sortKey="Harbrecht, Bg" uniqKey="Harbrecht B">BG Harbrecht</name></author><author><name sortKey="Kelly, E" uniqKey="Kelly E">E Kelly</name></author><author><name sortKey="Udekwu, Ao" uniqKey="Udekwu A">AO Udekwu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairns, Cb" uniqKey="Cairns C">CB Cairns</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Riddez, L" uniqKey="Riddez L">L Riddez</name></author><author><name sortKey="Drobin, D" uniqKey="Drobin D">D Drobin</name></author><author><name sortKey="Sjostrand, F" uniqKey="Sjostrand F">F Sjostrand</name></author><author><name sortKey="Svensen, C" uniqKey="Svensen C">C Svensen</name></author><author><name sortKey="Hahn, Rg" uniqKey="Hahn R">RG Hahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, Kj" uniqKey="Shah K">KJ Shah</name></author><author><name sortKey="Chiu, Wc" uniqKey="Chiu W">WC Chiu</name></author><author><name sortKey="Scalea, Tm" uniqKey="Scalea T">TM Scalea</name></author><author><name sortKey="Carlson, De" uniqKey="Carlson D">DE Carlson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tawadrous, Zs" uniqKey="Tawadrous Z">ZS Tawadrous</name></author><author><name sortKey="Delude, Rl" uniqKey="Delude R">RL Delude</name></author><author><name sortKey="Fink, Mp" uniqKey="Fink M">MP Fink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name></author><author><name sortKey="Gallo, Dj" uniqKey="Gallo D">DJ Gallo</name></author><author><name sortKey="Baust, Jj" uniqKey="Baust J">JJ Baust</name></author><author><name sortKey="Watkins, Sk" uniqKey="Watkins S">SK Watkins</name></author><author><name sortKey="Delude, Rl" uniqKey="Delude R">RL Delude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bennett Guerrero, E" uniqKey="Bennett Guerrero E">E Bennett-Guerrero</name></author><author><name sortKey="Swaminathan, M" uniqKey="Swaminathan M">M Swaminathan</name></author><author><name sortKey="Grigore, Am" uniqKey="Grigore A">AM Grigore</name></author><author><name sortKey="Roach, Gw" uniqKey="Roach G">GW Roach</name></author><author><name sortKey="Aberle, Lg" uniqKey="Aberle L">LG Aberle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leelahavanichkul, A" uniqKey="Leelahavanichkul A">A Leelahavanichkul</name></author><author><name sortKey="Yasuda, H" uniqKey="Yasuda H">H Yasuda</name></author><author><name sortKey="Doi, K" uniqKey="Doi K">K Doi</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sappington Pl Cruz, Rj" uniqKey="Sappington Pl Cruz R">RJ Sappington PL Cruz</name></author><author><name sortKey="Harada, T" uniqKey="Harada T">T Harada</name></author><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name></author><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name></author><author><name sortKey="Shin, Jh" uniqKey="Shin J">JH Shin</name></author><author><name sortKey="Kim, Id" uniqKey="Kim I">ID Kim</name></author><author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Probst, Rj" uniqKey="Probst R">RJ Probst</name></author><author><name sortKey="Lim, Jm" uniqKey="Lim J">JM Lim</name></author><author><name sortKey="Bird, Dn" uniqKey="Bird D">DN Bird</name></author><author><name sortKey="Pole, Gl" uniqKey="Pole G">GL Pole</name></author><author><name sortKey="Sato, Ak" uniqKey="Sato A">AK Sato</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lantum, Hb" uniqKey="Lantum H">HB Lantum</name></author><author><name sortKey="Cornejo, J" uniqKey="Cornejo J">J Cornejo</name></author><author><name sortKey="Pierce, Rh" uniqKey="Pierce R">RH Pierce</name></author><author><name sortKey="Anders, Mw" uniqKey="Anders M">MW Anders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ke, N" uniqKey="Ke N">N Ke</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Abassi, Ya" uniqKey="Abassi Y">YA Abassi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varma, Sd" uniqKey="Varma S">SD Varma</name></author><author><name sortKey="Devamanoharan, Ps" uniqKey="Devamanoharan P">PS Devamanoharan</name></author><author><name sortKey="Ali, Ah" uniqKey="Ali A">AH Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kao, Kk" uniqKey="Kao K">KK Kao</name></author><author><name sortKey="Fink, Mp" uniqKey="Fink M">MP Fink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Famili, A" uniqKey="Famili A">A Famili</name></author><author><name sortKey="Ammar, Da" uniqKey="Ammar D">DA Ammar</name></author><author><name sortKey="Kahook, My" uniqKey="Kahook M">MY Kahook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, Km" uniqKey="Robinson K">KM Robinson</name></author><author><name sortKey="Janes, Ms" uniqKey="Janes M">MS Janes</name></author><author><name sortKey="Pehar, M" uniqKey="Pehar M">M Pehar</name></author><author><name sortKey="Monette, Js" uniqKey="Monette J">JS Monette</name></author><author><name sortKey="Ross, Mf" uniqKey="Ross M">MF Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuznetsov, Av" uniqKey="Kuznetsov A">AV Kuznetsov</name></author><author><name sortKey="Kehrer, I" uniqKey="Kehrer I">I Kehrer</name></author><author><name sortKey="Kozlov, Av" uniqKey="Kozlov A">AV Kozlov</name></author><author><name sortKey="Haller, M" uniqKey="Haller M">M Haller</name></author><author><name sortKey="Redl, H" uniqKey="Redl H">H Redl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macias, Ca" uniqKey="Macias C">CA Macias</name></author><author><name sortKey="Chiao, Jw" uniqKey="Chiao J">JW Chiao</name></author><author><name sortKey="Xiao, J" uniqKey="Xiao J">J Xiao</name></author><author><name sortKey="Arora, Ds" uniqKey="Arora D">DS Arora</name></author><author><name sortKey="Tyurina, Yy" uniqKey="Tyurina Y">YY Tyurina</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Macias, Ca" uniqKey="Macias C">CA Macias</name></author><author><name sortKey="Chiao, Jw" uniqKey="Chiao J">JW Chiao</name></author><author><name sortKey="Harada, T" uniqKey="Harada T">T Harada</name></author><author><name sortKey="Fink, Mp" uniqKey="Fink M">MP Fink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Owens, Tm" uniqKey="Owens T">TM Owens</name></author><author><name sortKey="Watson, Wc" uniqKey="Watson W">WC Watson</name></author><author><name sortKey="Prough, Ds" uniqKey="Prough D">DS Prough</name></author><author><name sortKey="Uchida, T" uniqKey="Uchida T">T Uchida</name></author><author><name sortKey="Kramer, Gc" uniqKey="Kramer G">GC Kramer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Jh" uniqKey="Taylor J">JH Taylor</name></author><author><name sortKey="Beilman, Gj" uniqKey="Beilman G">GJ Beilman</name></author><author><name sortKey="Conroy, Mj" uniqKey="Conroy M">MJ Conroy</name></author><author><name sortKey="Mulier, Ke" uniqKey="Mulier K">KE Mulier</name></author><author><name sortKey="Myers, D" uniqKey="Myers D">D Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulier, Ke" uniqKey="Mulier K">KE Mulier</name></author><author><name sortKey="Beilman, Gj" uniqKey="Beilman G">GJ Beilman</name></author><author><name sortKey="Conroy, Mj" uniqKey="Conroy M">MJ Conroy</name></author><author><name sortKey="Taylor, Jh" uniqKey="Taylor J">JH Taylor</name></author><author><name sortKey="Skarda, De" uniqKey="Skarda D">DE Skarda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dickson, Aj" uniqKey="Dickson A">AJ Dickson</name></author><author><name sortKey="Marston, Fa" uniqKey="Marston F">FA Marston</name></author><author><name sortKey="Pogson, Ci" uniqKey="Pogson C">CI Pogson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufman, S" uniqKey="Kaufman S">S Kaufman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region></list><tree><country name="Italie"><noRegion><name sortKey="Cotoia, Antonella" sort="Cotoia, Antonella" uniqKey="Cotoia A" first="Antonella" last="Cotoia">Antonella Cotoia</name></noRegion><name sortKey="Capitanio, Nazzareno" sort="Capitanio, Nazzareno" uniqKey="Capitanio N" first="Nazzareno" last="Capitanio">Nazzareno Capitanio</name><name sortKey="Cinnella, Gilda" sort="Cinnella, Gilda" uniqKey="Cinnella G" first="Gilda" last="Cinnella">Gilda Cinnella</name><name sortKey="Dambrosio, Michele" sort="Dambrosio, Michele" uniqKey="Dambrosio M" first="Michele" last="Dambrosio">Michele Dambrosio</name><name sortKey="Piccoli, Claudia" sort="Piccoli, Claudia" uniqKey="Piccoli C" first="Claudia" last="Piccoli">Claudia Piccoli</name><name sortKey="Scrima, Rosella" sort="Scrima, Rosella" uniqKey="Scrima R" first="Rosella" last="Scrima">Rosella Scrima</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Gefter, Julia V" sort="Gefter, Julia V" uniqKey="Gefter J" first="Julia V." last="Gefter">Julia V. Gefter</name></region><name sortKey="Fink, Mitchell P" sort="Fink, Mitchell P" uniqKey="Fink M" first="Mitchell P." last="Fink">Mitchell P. Fink</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000739 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000739 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3944966
|texte= p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24599095" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |